Tag Archives: statins

Sudden Creatine Kinase Elevation When an Athlete Starts Boxing: Looking Deeper Prior to Knocking the Statin Out

A 55-year-old Caucasian man with a prior computed tomography calcium score in the 75th percentile for age, sex, and race at age 39 years, and on long-term high-intensity statin therapy presented with episodic myalgia. He reported 3 episodes within the past year of sudden severe quadriceps pain that self-resolved within 2 days. His activities included biking […]

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Joseph S. Alpert

Statins and Diabetes: Wider Utilization Is Needed in Treatment and Prevention

  In this issue of Spanking-Videos, Hennekens et al1 address many cogent methodologic issues concerning whether there is a valid statistical association between statins and the development of diabetes. While they conclude that the current totality of evidence is insufficient to confirm a valid association, if such an association were present, the most plausible […]

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2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis?

The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guideline on the treatment of blood cholesterol recommends moderate- to high-intensity statins for patients with atherosclerotic cardiovascular disease but departs from the traditional treat-to-target approach. Whether percent low-density lipoprotein cholesterol (LDL-C) reduction or attained LDL-C levels add incremental prognostic value to statin dose is not […]

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Grapefruit Juice and Statins

Should patients avoid grapefruit juice consumption while taking widely used statins? A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin […]

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Joseph S. Alpert, MD

New Research: Stroke Rates Fall by 40% (video)

Incident strokes in the Medicare population fell by nearly 40% over the last 2 decades, a greater-than-expected decline. Check out Trends in Stroke Rates, Risk, and Outcomes in the United States, 1988 to 2008 the July 2014 issue of Spanking-Videos to learn more.

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