Tag Archives: editorial
Dr. Joseph S. Alpert

Challenging Patients: An International Perspective

Recently, I related the sad stories of 2 challenging patients that I had helped to care for during one of my rotations as attending physician on our internal medicine service.1 The first patient was a frail elderly lady with a number of serious and potentially life-threatening illnesses who insisted on going home to her apartment where […]

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Association Between High-Density Lipoprotein Cholesterol and Hyponatremia

In this issue of The American Journal of Medicine Israel and Grossman1 report an interesting observation based on their analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) and the National Health and Nutrition Examination Survey (NHANES) datasets. They used gradient boosting machines to build predictive models for hyponatremia based on SPRINT participant high-density lipoprotein cholesterol (HDL-C) levels, […]

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Dr. Joseph S. Alpert

Stem Cell Therapy: The Phoenix in Clinical Medicine?

The Phoenix is a mythical bird with brightly colored plumage known in ancient Greek for the legend of its rebirth. After a long life, the Phoenix dies in a fire of its own making and then rises again reborn from the ashes. This myth parallels current feverish beliefs concerning the ability of stem cell therapy […]

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Joseph S. Alpert, MD

Polypharmacy in Elderly Patients: The March Goes On and On

Polypharmacy is a major public health problem in the United States and abroad. Although there is no standard definition of polypharmacy, I see and recognize it every day in the outpatient and inpatient environment. A typical example that I saw yesterday was an 84-year-old man admitted to our internal medicine service for worsening heart failure. […]

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Osteopathic Manipulation in Treatment of Musculoskeletal Chest Pain

Throughout most of my 29 years of practicing clinical cardiology, I was never really satisfied with treatments I employed in the treatment of musculoskeletal chest pain. This was especially true with the recognition of nonsteroidal anti-inflammatory drug complications. Now, at the end of primary clinical practice, I believe I have found a satisfactory treatment. My […]

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