Tag Archives: Drugs

Choosing Wisely? Measuring the Burden of Medications in Older Adults near the End of Life: Nationwide, Longitudinal Cohort Study

The burden of medications near the end of life has recently come under scrutiny, because several studies suggested that people with life-limiting illness receive potentially futile treatments. Methods We identified 511,843 older adults (>65 years) who died in Sweden between 2007 and 2013 and reconstructed their drug prescription history for each of the last 12 […]

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Leptomeningeal Infiltration, the Hallmark of Neurosarcoidosis

A 22-year-old human immunodefiency virus–negative man was admitted to the intensive care unit for generalized seizures. The patient’s family reported a 1-month history of asthenia and intermittent confusion. Clinical examination revealed isolated inappropriateness of behavior related to a frontal lobe syndrome, without any neck stiffness or neurologic deficit. The patient’s temperature was 37°C. Results from […]

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Why California’s Proposition 61 Was a Bad Idea

New approaches to control state pharmaceutical costs are needed.1 This issue is particularly critical in California, the state with the largest pharmaceutical expenditures in the country.1 A controversial California ballot initiative aimed at reining in prescription drug expenditures was defeated on November 8, 2016 by a 54% to 46% margin.2The California Drug Price Relief Act, also known […]

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Physician Exposure to Direct-to-Consumer Pharmaceutical Marketing

The American Medical Association’s 2015 recommendation to ban direct-to-consumer advertising (DTCA) of prescription drugs reflected a strong consensus that this form of marketing is a significant contributor to increased drug costs. It is well documented that many patients request drugs they have seen advertised on television and that physicians often acquiesce to these requests.1, 2, 3, 4 But the […]

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Nonsteroidal Anti-Inflammatory Drugs and Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Surgery

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in perioperative pain management of patients undergoing coronary artery bypass graft surgery. However, the association of periprocedural use of NSAIDs and clinical outcomes after coronary artery bypass graft is understudied. Methods We conducted a retrospective analysis using pooled data from 2 multicenter randomized controlled trials (PREVENT IV [n = […]

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