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Single High-Sensitivity Cardiac Troponin I to Rule Out Acute MI (video)

This study examined the performance of single high-sensitivity cardiac troponin I (hs-cTnI) measurement strategies to rule out acute myocardial infarction. Methods This was a prospective, observational study of consecutive patients presenting to the emergency department (n = 1631) in whom cTnI measurements were obtained using an investigational hs-cTnI assay. The goals of the study were to […]


Chest Pain and Elevated Troponins in a Patient with Prior Coronary Artery Disease: A Diagnostic Dilemma

More than one quarter of patients hospitalized with congestive heart failure are readmitted within 30 days of discharge, with total annual costs surpassing $20 billion. In patients presenting with acute heart failure symptoms and chest pain, differentiating acute coronary syndrome from acute myocarditis is challenging. Newer imaging modalities, such as cardiac magnetic resonance imaging, can […]


Lab Tests Don’t Make Diagnoses, Doctors Do

During the last 10 years, I have been involved in a process that sought to create a clinical definition of myocardial infarction that could and would be used universally by clinicians and clinical investigators throughout the world. The impetus for this task was the observation that clinicians in different hospitals, and even within the same […]