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Dr. Joseph S. Alpert

Challenging Patients: An International Perspective

Recently, I related the sad stories of 2 challenging patients that I had helped to care for during one of my rotations as attending physician on our internal medicine service.1 The first patient was a frail elderly lady with a number of serious and potentially life-threatening illnesses who insisted on going home to her apartment where […]

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woman holding a pill and glass of water

From Evidence Based Medicine to Medicine Based Evidence

Evidence based medicine, using randomized controlled trials and meta-analyses as the major tools and sources of evidence about average results for heterogeneous groups of patients, developed as a reaction against poorly designed observational treatment research and physician reliance on personal experience with other patients as a guide to decision-making about a patient at hand. However, […]

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Achieving Extended Longevity and Quality of Life for Senior Patients With Hypertrophic Cardiomyopathy

To read this article in its entirety please visit our website. – This article originally appeared in the November 2017 issue of The American Journal of Medicine.

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American Journal of Medicine Editor Joseph Alpert

‘Lies, Damned Lies, and Statistics’: Biostatistics and Prognostication for Patients

Quite often patients ask me to predict the future outcome of their illness: “How long can I expect to live with this illness, doctor, or how dangerous is the procedure that you are recommending?” A facile answer involves quoting data taken from clinical or epidemiologic studies, but this kind of information is rarely useful for […]

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Bone Density Testing Is the Best Way to Monitor Osteoporosis Treatment

Bone mineral density assessment by dual-energy X-ray absorptiometry is the most widely available and best validated clinical tool to diagnose osteoporosis, assess fracture risk, and monitor the skeletal effects of medications that reduce fracture risk.1 However, dual-energy X-ray absorptiometry testing remains underused with osteoporosis undertreated. This treatment gap has reached crisis proportions,2 with recent disturbing evidence that […]

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