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Hepatocellular Carcinoma Screening Associated with Early Tumor Detection and Improved Survival Among Patients with Cirrhosis in the US

Professional societies recommend hepatocellular carcinoma screening in patients with cirrhosis, but high-quality data evaluating its effectiveness to improve early tumor detection and survival in “real world” clinical practice are needed. We aim to characterize the association between hepatocellular carcinoma screening and early tumor detection, curative treatment, and overall survival among patients with cirrhosis. Methods We […]

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Not Just Skin Deep: Distant Metastases from Cutaneous Squamous Cell Carcinoma

  Cutaneous squamous cell carcinoma is the second most common cancer in the United States and has 5-year recurrence and metastasis rates of 8% and 5%, respectively.1, 2 However, not all cutaneous squamous cell carcinomas are alike, and the size and location of the primary lesion confers a widely variable risk for recurrence and metastasis. Case Summary […]

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Subcutaneous Lesion in an Oncologic Patient

A 40-year-old Caucasian woman presented to our university hospital after she noticed a mass in the right supraclavicular area. The lump was easily palpable, sized 1-1.5 cm, firm, and rather immovable, with surrounding edema (Figure 1). She had noticed the lesion approximately 2 weeks earlier, and during that time the mass was gradually enlarging. Her personal […]

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Hypertestosteronemia and Infertility from a Mediastinal Extragonadal Germ Cell Tumor

Extragonadal germ cell tumors are tumors of gonadal origin representing less than 5% of germ cell malignancies that form outside gonads. These are typically found in the mediastinum, retroperitoneum, or pineal gland. A 26-year-old man presented to the infertility clinic in January 2016 with a 2-year history of infertility. He had known hypertrophic cardiomyopathy due […]

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Independent of Cirrhosis, Hepatocellular Carcinoma Risk Is Increased with Diabetes and Metabolic Syndrome

Hepatocellular carcinoma is the most common primary liver malignancy, commonly a sequelae of hepatitis C infection, but can complicate cirrhosis of any cause. Whether metabolic syndrome and its components, type II diabetes, hypertension, and hyperlipidemia increase the risk of hepatocellular carcinoma independent of cirrhosis is unknown. Methods A retrospective cohort study was conducted using the MarketScan insurance […]

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