American Journal of Medicine, internal medicine, medicine, health, healthy lifestyles, cancer, heart disease, drugs

Acute Calcific Tendinitis of the Longus Colli Muscle

A 47-year-old healthy woman presented with sudden-onset, severe neck pain and stiffness associated with odynophagia, dysphagia, and low-grade fever (37.8°C). She described it as severe neck pain extending into the deep neck and radiating upward to the occiput and vertex of the head. She also complained of difficulty in opening her jaw and swallowing due […]

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Connecting the Dots: A Case of Myeloid Sarcoma

A 73-year-old white gentleman with a medical history significant for stage IIA (pT3a, N0, M0) malignant melanoma managed by wide local excision from his right shoulder was referred to our cutaneous clinic for evaluation of locally recurrent disease. An excisional biopsy of the lesion 3 months prior had been interpreted as consistent with malignant melanoma, […]

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handgun painted with american flag

Twenty Children, Six Teachers, Two Sets of Eyes, a Dog, and a Transformation

Twenty children, six teachers, two sets of eyes, and a dog were a terribly tragic catalyst for my metamorphosis as a physician and person. Let me explain. Until the cataclysmic event, I was an academic physician at an Ivy League institution who worshipped at the altar of evidence-based medicine and thought housestaff and students should […]

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Tophaceous Gout of Lumbar Spine with Fever Mimicking Infection

A 56-year-old man was admitted with complaints of low back pain and fever lasting for about 2 months. He had a 10-year history of intermittent gouty arthritis in his feet, which was being treated with colchicine, with the most recent attack occurring 12 months before. Assessment On physical examination, his body temperature was 38.5°C. His […]

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Brought Down by a Mosquito? West Nile Virus Encephalitis

  Neurologic symptoms in a previously healthy man spurred a battery of tests to determine the cause. The 51-year-old patient lived alone and was transferred to our intensive care unit from another facility. Emergency medical services personnel first brought him to his local emergency department, where he stated that he had not been feeling well […]

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doctor uses tablet with patient

Twenty-Five-Year (1986-2011) Trends in the Incidence and Death Rates of Stroke Complicating Acute Myocardial Infarction

The occurrence of a stroke after an acute myocardial infarction is associated with increased morbidity and mortality rates. However, limited data are available, particularly from a population-based perspective, about recent trends in the incidence and mortality rates associated with stroke complicating an acute myocardial infarction. The purpose of this study was to examine 25-year trends […]

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The Lifespan of Genetic Testing

Genetic testing is now more commonplace in clinical medicine owing largely to improvements in sequencing technology. Genetic results enable greater diagnostic certainty with important prognostic and therapeutic implications. Nevertheless, it is important to consider the longitudinal relationship created between the provider, the patient, and his or her family. This relationship can extend long beyond the […]

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doctor testing for blood pressure

Development and Preliminary Feasibility of an Automated Hypertension Self-Management System

Uncontrolled hypertension constitutes a significant challenge throughout the world. Blood pressure measurement by patients is informative for both patients and providers but is rarely performed systematically, thereby reducing its utility. Mobile phones can be used to efficiently prompt individuals to measure blood pressure and automate data management while avoiding technology barriers to widespread adoption. Presented […]

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2017 Is Banner Year for Drug Approvals by the Food and Drug Administration

In 2017, the US Food and Drug Administration (FDA) approved 46 novel drugs, a 21-year high,1, 2, 3 and an additional 29 previously approved drugs received newly approved indications. This record setting year was due, in part, to several new expedited review pathways at the FDA, including accelerated approval, priority review, and fast-track and breakthrough therapy, all of […]

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Joseph S. Alpert

Diet Redux: Which Food Type Leads to Heart Attacks?

No topic has been more hotly debated over recent decades than the role of various foods in the development of atherosclerosis. The earliest animal experiments demonstrated that diets rich in fat and cholesterol produced arterial lesions that resembled atherosclerosis in humans.1 Over subsequent decades, a great deal of animal and human research has been performed exploring […]

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